Clinical Studies and Case-Based Evidence

Our groundbreaking technology has been developed over the last 10+ years in collaboration with pediatric dentists, families and the scientific community. A select list of clinical and case studies is presented below.

A close-up 3D graphic render demonstrating the mouthpiece attachment of a white and blue automated toothbrush interacting with a model of human gums and teeth. The white bristles are shown angled along the gumline of pink upper and lower dental arches to illustrate comprehensive bristle contact.

Here’s What the Science Says:

According to the ADA, plaque is the root cause of tooth decay (cavities) and gum diseases.


Willo is designed to address the well-documented limitations of pediatric brushing, where developing dexterity and inconsistent technique lead to uneven plaque removal. By automating the process, Willo reduces user-dependent variability and supports more consistent plaque disruption than manual brushing alone.

Bar chart showing plaque reduction after brushing with Willo compared to an ADA approved manual toothbrush.

Study 1 Summary

A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

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Before and after comparison of teeth brushed with Willo automatic toothbrush

Study 2 Summary

A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

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Bar chart showing plaque reduction after brushing with Willo compared to an ADA approved manual toothbrush.

Study 3 Summary

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Clinical efficacy data chart comparing the Willo automated mouth toothbrush to a standard manual toothbrush. The infographic displays data metrics for plaque removal across specific anatomical mouth sectors, including lingual gingival and whole mouth areas, demonstrating Willo's statistically superior plaque reduction performance backed by a 2024 clinical study.

Study 1 Summary

A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

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A close-up dental comparison image showing "Before" and "After" views of a child's teeth using a pink plaque disclosing solution. The top "Before" image displays prominent pink plaque accumulation along the gumline, while the bottom "After" image shows clean teeth with significantly reduced plaque coverage following a brushing cycle.

Study 2 Summary

A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

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Placeholder Study 3

A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

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Study 1

  • Clinical trial data infographic for the Willo automated mouth toothbrush showing plaque reduction efficacy metrics. The asset details results from a randomized, examiner-blinded clinical study comparing the device against an ADA-approved manual toothbrush in children aged 5 to 13 years old, proving superior clinical performance across multiple dental regions including whole mouth and lingual gingival sectors.

    Study Summary

    A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

    On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

    Download Study 

Study 2

  • Before and after comparison of teeth with pinkish discoloration.

    Study Summary

    An early clinical evaluation of the Willo prototype brushing device was conducted to assess comfort, usability, plaque removal efficacy, and gingival safety. Five pediatric subjects participated. Pre- and post-brushing plaque levels demonstrated significant plaque removal across all participants, with an average index-based reduction exceeding 50%. The device was well tolerated and used successfully by all subjects.

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Bar chart showing plaque reduction after brushing with Willo compared to an ADA approved manual toothbrush.

Study 1 Summary

A rigorous clinical study tested Willo against a top-rated manual toothbrush approved by the American Dental Association. The results were clear: kids aged 5 to 13 who used Willo had significantly less plaque after just one brushing session.

On average, Willo removed 60% of plaque, compared to only 20–25% with a manual brush. It was especially effective in hard-to-reach spots — like the back of the mouth — removing up to 7 times more plaque than the manual toothbrush.

Download Study